C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/30 (2006.01) A61K 49/00 (2006.01) A61K 49/16 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2454784
A method is described for the identification of specific tumour antigens by means of the selection of cDNA display libraries by using sera characterised in that said selection is accomplished with the phage display technique, and in particular said selection is accomplished by means of the SEREX technique (serological analysis of autologous tumour antigens through the expression of recombinant cDNA). The method according to the invention described herein advantageously combines the SEREX approach with the potency of the phage display technique defined above, at the same time avoiding the drawbacks characteristic of the SEREX technique.
L'invention concerne un procédé d'identification d'antigènes de tumeur spécifiques par la sélection de bibliothèques d'affichage d'ADNc en utilisant la technique SERA caractérisée par le fait que ladite sélection est accomplie par la technique d'affichage phage et qu'en particulier ladite sélection est réalisée au moyen de la technique SEREX (analyse sérologique d'antigènes de tumeur autologues par l'expression d'ADNc recombinante). Ce procédé associe de manière avantageuse la technique SEREX et la capacité de la technique d'affichage phage définie ci-dessus, tout en évitant les inconvénients liés à la technique SEREX.
Felici Franco
Minenkova Olga
Fetherstonhaugh & Co.
Kenton S.r.l.
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