Identification of the gene causing the mouse scurfy...

Details Identification of the gene causing the mouse scurfy... Identification of the gene causing the mouse scurfy...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 15/63 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2339409

Isolated nucleic acid molecules are provided which encode Fkhsf, as well as mutant forms thereof. Also provided are expression vectors suitable for expressing such nucleic acid molecules, and host cells containing such expression vectors. Utilizing assays based upon the nucleic acid sequences disclosed herein (as well as mutant forms thereof), numerous molecules may be identified which modulate the immune system.

L'invention concerne des molécules d'acide nucléique codant Fkh?sf¿ et des formes mutantes de Fkh?sf¿. L'invention concerne également des vecteurs d'expression pouvant exprimer les molécules d'acide nucléique, et des cellules hôtes contenant lesdits vecteurs d'expression. L'utilisation de dosages biologiques basés sur des séquences de l'acide nucléique de l'invention (ainsi que de leurs formes mutantes) permet d'identifier de nombreuses molécules modifiant le système immunitaire.

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