A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) C07K 7/06 (2006.01) C07K 14/16 (2006.01)
Patent
CA 2756238
The present invention pertains to methods for identifying a HLA-A* 2402- restricted cryptic epitope in an antigen, and for increasing its immunogenicity, in order to obtain HLA-A*2402- restricted epitopes able to trigger an immune response against HLA- A*2402-restricted cryptic epitopes. Isolated peptides consisting of cryptic or optimized HLA- A*2402-restricted epitopes are provided.
La présente invention porte sur des procédés pour identifier un épitope cryptique spécifique à HLA-A*2402 dans un antigène, et pour augmenter son immunogénicité, afin d'obtenir des épitopes spécifiques à HLA-A*2402 capables de déclencher une réponse immunitaire dirigée contre des épitopes cryptiques spécifiques à HLA-A*2402. L'invention porte sur des peptides isolés consistant en des épitopes spécifiques à HLA-A*2402 cryptiques ou optimisés.
Kosmatopoulos Kostantinos (kostas)
Menez-Jamet Jeanne
Robic
Vaxon Biotech
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