Idiotypic vaccination against b cell lymphoma

Details Idiotypic vaccination against b cell lymphoma Idiotypic vaccination against b cell lymphoma

C - Chemistry, Metallurgy

12

N

C12N 5/08 (2006.01) A61K 39/00 (2006.01) C07K 16/42 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2078235

The invention provides a method of inducing an effective immune response to pathogenic lymphocytes by administering dendritic cells previously pulsed with the idiotype protein of interest. In one embodiment, a method for the active immunization of a mammal against lymphoma is provided. This embodiment comprises exposing dendritic cells to idiotype 1g to make idiotype pulsed dendritic cells and injecting the idiotype pulsed dendritic cells back into the mammal, whereby immunity against lympho- ma cells is induced. 1n another embodiment, the invention relates to the administration of both idiotypic cells and pulsed dendri- tie cells.

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