Ifbm's to promote attachment of target analytes

Details Ifbm's to promote attachment of target analytes Ifbm's to promote attachment of target analytes

C - Chemistry, Metallurgy

07

K

C07K 7/06 (2006.01) A61L 27/22 (2006.01) A61L 27/34 (2006.01) C07K 7/08 (2006.01) C12N 5/077 (2010.01) C07K 14/51 (2006.01) C07K 17/00 (2006.01)

Patent

CA 2569864

The present invention provides an improved coating for surfaces of medical implants. The coating comprises at least one interfacial biomaterial (IFBM) which is comprised of at least one binding module that binds to the surface of an implant or implant-related material (~implant module~) and at least one binding module that selectively binds to a target analyte or that is designed to have a desired effect (~analyte module~). The modules are connected by a linker. In some embodiments, the IFBM coating acts to promote the recognition and attachment of target analytes to surface of the device. The IFBM coating improves the performance of implanted medical devices, for example, by promoting osteointegration of the implant.

La présente invention a trait à un revêtement amélioré pour des surfaces d'implants médicaux. Le revêtement comporte au moins un biomatériau d'interface qui comprend au moins un module de liaison assurant la liaison à la surface d'un implant ou de matériau associé à un implant ("module d'implant") et au moins un module de liaison qui assure la liaison sélective à un analyte cible ou qui est destiné à avoir un effet souhaitable ("module d'analyte"). Les modules sont liés par un lieur. Dans certains modes de réalisation, le revêtement à base de biomatériau d'interface agit pour favoriser l'identification et la liaison d'analytes cibles à la surface du dispositif. Le revêtement à base de biomatériau d'interface améliore la performance de dispositifs médicaux implantés, par exemple, en favorisant l'ostéointégration de l'implant.

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