Ifn-.beta. liquid formulations

Details Ifn-.beta. liquid formulations Ifn-.beta. liquid formulations

A - Human Necessities

61

K

A61K 38/21 (2006.01) A61K 47/26 (2006.01) A61K 47/42 (2006.01) A61K 47/12 (2006.01)

Patent

CA 2190465

Interferon-beta liquid formulations stabilized with a polyol, a non-reducing sugar or an amino acid. In particular, the formulations are stabilized with a polyol, such as mannitol. The formulations, preferably furthermore comprise a buffer, such as acetate buffer, at a pH comprised between 3.0 and 4.0 and human albumin at a minimum quantity. The interferon-beta is preferably recombinant.

Formulations liquides d'interféron bêta stabilisées à l'aide d'un polyol, d'un sucre non réducteur ou d'un acide aminé. Plus spécialement, les formulations sont stabilisées à l'aide d'un polyol tel que le mannitol. De préférence, ces formulations comportent également un tampon tel qu'un tampon d'acétate, dont le pH est compris entre 3,0 et 4,0, ainsi qu'une quantité minimale d'albumine humaine. De préférence, l'interféron bêta est recombiné.

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