C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/21 (2006.01) A61K 39/395 (2006.01) C07H 21/02 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/00 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2132317
2132317 9319179 PCTABS00025 Receptor recognition factors exist that recognize the specific cell receptor to which a specific ligand has been bound, and that may thereby signal and/or initiate the binding of the transcription factor to the DNA site. The receptor recognition factor is in one instance, a part of a transcription factor, and also may interact with other transcription factors to cause them to activate and travel to the nucleus for DNA binding. The receptor recognition factor appears to be second-messenger-independent in its activity, as overt perturbations in second messenger concentrations are of no effect. The concept of the invention is illustrated by the results of studies conducted with interferon (IFN)-stimulated gene transcription, and particularly, the activation caused by both IFN.alpha. and IFN.gamma.. Specific DNA sequences have been prepared that correspond to polypeptide fragments of two of the ISGF-3 genes, and antibodies have also been prepared and tested. The polypeptides confirm direct involvement of tyrosine kinase in intracellular message transmission. Numerous diagnostic and therapeutic materials and utilities are also disclosed.
Darnell James E. Jr.
Fu Xin-Yuan
Schindler Christian W.
Shuai Ke
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Rockefeller University (the)
LandOfFree
Ifn receptors recognition factors, protein sequences and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Ifn receptors recognition factors, protein sequences and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Ifn receptors recognition factors, protein sequences and... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1458532