Iga nephropathy-related dna

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12P 21/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2329683

A novel DNA whose expression level fluctuates in leukocytes of IgA nephropathy patients in comparison with leukocytes of healthy persons, a process for isolating the DNA, a novel protein encoded by the DNA, an antibody recognizing the protein, methods for detecting the protein and the DNA, and methods of diagnosis and treatment of IgA nephropathy.

Cette invention a trait à un nouvel ADN ne s'exprimant pas de la même manière dans les leucocytes de patients atteints d'une glomérulonéphrite à dépôts mésangiaux d'IgA et dans les leucocytes de sujets sains. Elle porte également sur une technique permettant d'obtenir cet ADN, sur une nouvelle protéine codée par cet ADN ainsi que sur un anticorps reconnaissant cette protéine. Elle concerne, de surcroît, des méthodes de détection de la protéine et de l'ADN susmentionnés ainsi que des méthodes diagnostiques et thérapeutiques relatives à la glomérulonéphrite à dépôts mésangiaux d'IgA.

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