Iga1 protease fragment as carrier peptide

Details Iga1 protease fragment as carrier peptide Iga1 protease fragment as carrier peptide

C - Chemistry, Metallurgy

12

N

C12N 9/52 (2006.01) A61K 39/095 (2006.01) A61K 39/385 (2006.01)

Patent

CA 2249409

The present invention is concerned with a fragment of IgA1-protease having 40 to 200 amino acid residues and comprising at least 40 amino acids of an amino acid sequence as shown in SEQ ID NO 1, beginning with the amino acid in any one of positions 1 to 5 and ending with an amino acid in any one of positions 40 to 104 or a homologuous sequence, its use as a carrier for a conjugate, particularly in combination with a polysaccharide, and a process for producing the peptide as well as vaccines comprising said peptide.

L'invention possède un fragment de protéase-IgA1 possédant 40 à 200 résidus d'acides aminés et contenant au moins 40 acides aminés d'une séquence d'acides aminés telle qu'elle est illustrée par SEQ ID NO 1, commençant par un acide aminé dans toute position de 1 à 5 et finissant par un acide aminé dans toute position de 40 à 104 ou une séquence homologue, son utilistion en tant que véhicule pour un conjugué, en particulier, en combinaison avec un polysaccharide, et un procédé servant à préparer ce peptide, ainsi que des vaccins contenant ce peptide.

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