Ige receptor antagonists

Details Ige receptor antagonists Ige receptor antagonists

C - Chemistry, Metallurgy

07

K

C07K 14/00 (2006.01) C07K 7/08 (2006.01) C07K 16/00 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2420475

The invention provides novel compounds which bind to the high affinity receptor for immunoglobulin E (IgE) designated Fc.epsilon.RI and methods for identifying and preparing such compounds. In particular aspects, the invention provides to the treatment of disorders mediated by IgE utilizing the novel compounds of the invention. The invention also provides compositions, such as pharmaceutical compositions, comprising the novel compounds, as well as for their use in research, diagnostic, therapeutic, and prophylactic methods.

L'invention concerne de nouveaux composés se liant à un récepteur de haute affinité pour l'immunoglobuline E (igE), désigné par Fc.epsilon.RI, ainsi que des procédés d'identification et de préparation de tels composés. Sous des aspects particuliers, l'invention concerne le traitement de troubles occasionnés par IgE, traitement utilisant les nouveaux composés de l'invention. L'invention concerne en outre des compositions, telles que des compositions pharmaceutiques, renfermant les nouveaux composés, ainsi que leur utilisation en recherche et dans des méthodes de diagnostic, thérapeutiques et prophylactiques.

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