A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/30 (2006.01) C07K 14/65 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2135306
2135306 9323067 PCTABS00028 Pharmaceutical compositions which comprise short peptides which function as IGF-1 receptor antagonists are provided. The peptides used in the pharmaceutical compositions of the invention consist of less than 25 amino acids, comprise at least a portion of the C or D domain from IGF-1 and inhibit IGF-1 induced autophosphorylation of IGF-1 receptors. Methods of inhibiting cell proliferation and of treating individuals suspected of suffering from or susceptible to diseases associated with undesirable cell proliferation such as cancer, restenosis and asthma are disclosed.
Baserga Renato
Jameson Bradford A.
Smart & Biggar
Thomas Jefferson University
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