Igf-1 analogs

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/30 (2006.01) C07K 14/65 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2135306

2135306 9323067 PCTABS00028 Pharmaceutical compositions which comprise short peptides which function as IGF-1 receptor antagonists are provided. The peptides used in the pharmaceutical compositions of the invention consist of less than 25 amino acids, comprise at least a portion of the C or D domain from IGF-1 and inhibit IGF-1 induced autophosphorylation of IGF-1 receptors. Methods of inhibiting cell proliferation and of treating individuals suspected of suffering from or susceptible to diseases associated with undesirable cell proliferation such as cancer, restenosis and asthma are disclosed.

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