Igf-1 as feline vaccine adjuvant, in particular against...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/18 (2006.01) A61K 31/7088 (2006.01) A61K 39/00 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) A61K 47/42 (2006.01) A61K 48/00 (2006.01) C07K 14/15 (2006.01) C07K 14/65 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2459769

The invention relates to feline IGF-1, to the nucleotide sequence encoding this protein and to the use of IGF-1 as adjuvant for the vaccination of cats, in particular against the feline retroviruses FIV and FeLV. IGF-1 may be used in the form of protein or may be expressed in vivo by a suitable, e.g. viral or plasmid, expression vector. The invention relates to all types of vaccines, namely inactivated, attenuated, sub-unit and recombinant vaccines. The vectors expressing IGF-1 in vivo may also be used in immunity-stimulating compositions.

L'invention concerne le facteur de croissance félin IGF-1, la séquence nucléotidique codant pour cette protéine et l'utilisation de IGF-1 comme adjuvant pour la vaccination des chats, notamment contre les rétrovirus félins FIV et FeLV. IGF-1 peut être utilisé sous forme de protéine ou peut être exprimé in vivo par un vecteur d'expression approprié, par exemple, viral ou plasmide. L'invention concerne également tous les types de vaccins, à savoir des sous-unités et des vaccins de recombinaison inactivés et atténués. On peut également utiliser les vecteurs exprimant IGF-1 in vivo dans des compositions stimulant l'immunité.

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