Igf binding proteins

Details Igf binding proteins Igf binding proteins

C - Chemistry, Metallurgy

07

K

C07K 14/65 (2006.01) C07K 14/31 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 15/62 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2541015

IGFBP-3 fusion proteins are provided that are useful, for example, in cell- based assays, as IGF antagonists, and in mapping IGF-I and IGF-II binding sites on other molecules such as wild-type IGFBP-3 and IGF agonist peptides identified by phage display. Methods for making such fusion proteins are also provided.

L'invention concerne des protéines hybrides IGFBP-3 utiles, par exemple, comme antagonistes dans des dosages cellulaires, et pouvant également être utilisées pour la cartographie de sites de liaison à l'IGF-I et à l'IGF-II sur d'autres molécules, telles que l'IGFBP-3 de type sauvage et les peptides agonistes de l'IGF identifiés par la méthode d'expression phagique. L'invention concerne en outre des méthodes de production desdites protéines hybrides.

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