Igf-ii/gf-iie binding proteins

Details Igf-ii/gf-iie binding proteins Igf-ii/gf-iie binding proteins

C - Chemistry, Metallurgy

07

K

C07K 16/26 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2723722

Proteins that bind to IGF-II and/or IGF-IIE and methods of using such proteins are described. Also disclosed are new methods for treatment of cancer. Cancer is treated by administration of an IGF-II/GF-IIE binding protein and an additional therapy such as a growth hormone/growth hormone releasing hormone pathway modulator or epidermal growth factor receptor inhibitor.

La présente invention concerne des protéines qui lient l'IGF-II et/ou l'IGF-IIE, ainsi que des procédés d'utilisation desdites protéines. L'invention concerne également des procédés inédits de traitement du cancer. Le cancer est traité grâce à l'administration d'une protéine liant l'IGF-II/IGF-IIE et d'une autre substance thérapeutique telle qu'une hormone de croissance/un modulateur de la voie hormonale de libération de l'hormone de croissance ou un inhibiteur du récepteur du facteur de croissance épidermique.

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