Igf-ir antagonists as adjuvants for treatment of prostate...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 31/277 (2006.01) A61K 31/519 (2006.01) A61K 31/7105 (2006.01) A61K 38/09 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) A61N 5/00 (2006.01)

Patent

CA 2641310

The present invention relates to a method of treating prostate cancer with androgen deprivation therapy and an insulin-like growth factor receptor (IGF-IR) antagonist. Although the response rate of prostate cancer to androgen deprivation therapy (ADT) is high, surviving cancer cells invariably become androgen independent (AI) and tumor growth follows. The invention inhibits or delays transition of androgen dependent cancer to androgen independent cancer, significantly decreases risk of recurrence, and improves treatment outcome.

La présente invention concerne une méthode de traitement du cancer de la prostate par thérapie par privation androgénique et utilisation d'un antagoniste du récepteur du facteur de croissance insulinoïde (IGF-IR). Bien que le taux de réponse du cancer de la prostate à la thérapie par privation androgénique soit élevé, les cellules cancéreuses survivantes deviennent indépendantes des androgènes (AI) avec pour conséquence une croissance de la tumeur. Cette invention permet d'inhiber ou de retarder le passage d'un cancer dépendant des androgènes à un cancer indépendant des androgènes, ce qui réduit sensiblement les risques de récurrence et améliore le pronostic thérapeutique.

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