Igg separation medium and novel protein a variant

Details Igg separation medium and novel protein a variant Igg separation medium and novel protein a variant

C - Chemistry, Metallurgy

07

K

C07K 1/22 (2006.01) C07K 16/06 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2236900

A separation medium comprising a base matrix and matrix-bound groups which exhibit recombinant Protein A containing a cysteine. The groups comply with the formula: - B - X - rProtein A-cys where B is a bridge which binds to the base matrix and X includes a heteroatom N or S from rProtein A-cys. The characterizing feature is that X is thioether sulphur and/or a secondary amine (-NH-). Protein A variant characterized in that the C-terminal residue is cysteine.

La présente invention concerne un milieu de séparation constitué d'une matrice base et de groupes liés à la matrice et qui comportent une Protéine A de recombinaison contenant une cystéine. Ces groupes sont représentés par la formule - B - X-rProtéine A-cys. Dans cette formule, B est un pont qui est lié à la matrice de base et X inclut un hétéroatome N ou S issu de la rProtéine A-cys. La caractéristique en est que X est un thioéther soufre et/ou une amine secondaire (-NH-). Ce qui caractérise le variant de la Protéine A est que le groupe C-terminal est la cystéine.

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