Igs as modifiers of the p53 pathway and methods of use

Details Igs as modifiers of the p53 pathway and methods of use Igs as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) C12Q 1/42 (2006.01) C12Q 1/48 (2006.01) C12Q 1/527 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2449136

Human IG genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of IG are provided.

L'invention concerne des gènes IG humains identifiés comme modulateurs de la voie p53, qui sont donc des cibles thérapeutiques pour des troubles associés à une fonction p53 défectueuse. L'invention concerne également des méthodes d'identification des modulateurs de p53, ces méthodes consistant à dépister des agents qui modulent l'activité de IG.

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