Ikb kinases

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 1/14 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12N 1/20 (2006.01) C12N 5/00 (2006.01) C12N 9/12 (2006.01) C12N 15/00 (2006.01) C12Q 1/48 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2281895

The invention provides methods and compositions relating to IB regulating proteins, known as T2K proteins, and related nucleic acids. The proteins may be produced recombinantly from transformed host cells from the disclosed T2K encoding nucleic acid or purified from human cells. The invention provides specific hybridization probes and primers capable of specifically hybridizing with the disclosed T2K gene, T2K-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

L'invention concerne des procédés et des compositions faisant intervenir des protéines régulatrices I?B, connues sous le nom de protéines T2K, et des acides nucléiques apparentés. Ces protéines peuvent être produites par recombinaison de cellules hôtes transformées à partir des T2K susmentionnées codant un acide nucléique, ou peuvent être purifiées de cellules humaines. L'invention concerne également des sondes et des amorces d'hybridation, capable de s'hybrider spécifiquement avec le gène T2K susmentionné. L'invention concerne enfin des agents de fixation spécifiques au T2K, tels que des anticorps spécifiques, ainsi que des procédés de fabrication et d'utilisation des compositions susmentionnées dans le diagnostic, la thérapie, et l'industrie biopharmaceutique.

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