Ikk-.alpha. proteins, nucleic acids and methods

Details Ikk-.alpha. proteins, nucleic acids and methods Ikk-.alpha. proteins, nucleic acids and methods

C - Chemistry, Metallurgy

12

N

C12N 15/54 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2294566

The invention provides methods and composiitons relating to an I.KAPPA. B kinase, IKK-.alpha., and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed IKK-.alpha. encoding nucleic acids or purified from human cells, The invention provides isolated IKK-.alpha. hybridization probes and primers capable of specifically hybridizing with the disclosed IKK-.alpha. genes, IKK-.alpha.-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.

Cette invention concerne des procédés et des compositions concernant une kinase I kappa B, IKK- alpha et les acides nucléiques associées. On peut produire les polypéptides par recombinaison à partir de cellules hôtes transformées tirées des acides nucléiques codant IKK- alpha décrits ou les purifier à partir de cellules humaines. Cette invention concerne également des sondes et des amorces d'hybridation de IKK- alpha isolées capables d'une hybridation spécifique avec les gênes IKK- alpha décrits, des agents de liaison spécifiques à IKK- alpha , tels que des anticorps spécifiques, ainsi que des procédés de production et d'utilisation de ces compositions en diagnostic, en thérapie et dans l'industrie biopharmaceutique.

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