Il-1.alpha. abs and methods of use

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/13 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) G01N 1/40 (2006.01) G01N 33/577 (2006.01)

Patent

CA 2726345

Fully human monoclonal Abs includes (i) an antigen-binding variable region that exhibits very high binding affinity for IL- 1.alpha. and (ii) a constant region that is effective at both activating the complement system though CIq binding and binding to several different Fc receptors.

L'invention porte sur un anticorps monoclonal entièrement humain qui comprend (i) une région variable de liaison à l'antigène qui présente une très forte affinité de liaison pour IL- la, et (ii) une région constante qui est efficace pour activer le système du complément à la fois par liaison à CIq et liaison à plusieurs récepteurs Fc différents.

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