Il-1.beta. binding antibodies and fragments thereof

Details Il-1.beta. binding antibodies and fragments thereof Il-1.beta. binding antibodies and fragments thereof

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61P 37/06 (2006.01) C07K 16/24 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) C12N 15/85 (2006.01) C12P 21/08 (2006.01) C07K 14/545 (2006.01)

Patent

CA 2612760

An IL- 1.beta. binding antibody or IL- 1.beta. binding fragment thereof comprising the amino acid sequence of SEQ ID NO: 2, and related nucleic acids, vectors, cells, and compositions, as well as method of using same to treat or prevent a disease, and a method of preparing an affinity matured IL- 1.beta. binding polypeptide. IL- 1.beta.binding antibodies or IL- 1.beta. binding fragments thereof are provided which have desirable affinity and potency.

L'invention se rapporte à un anticorps bloquant IL- 1ß ou à un de ses fragments bloquant IL- 1ß et présentant la séquence d'aminoacides de SEQ ID NO: 2, l'invention se rapporte également à des acides nucléiques, des vecteurs, des cellules et des compositions associées; l'invention concerne également un procédé d'utilisation desdits anticorps et fragments dans le traitement ou la prévention d'une maladie, ainsi qu'un procédé de préparation d'un polypeptide bloquant IL- 1ß présentant une maturation d'affinité. L'invention concerne également des anticorps bloquant IL- 1ß ou des fragments de ces derniers bloquant IL- 1ß, lesdits anticorps et fragments présentant une affinité et un pouvoir antigénique désirables.

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