C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/54 (2006.01) C07H 21/00 (2006.01) C07K 7/08 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2257373
Purified and isolated IL-1/TNF-.alpha.-activated kinase (ITAK), nucleic acids encoding ITAK, processes for production of recombinant forms of ITAK, pharmaceutical compositions containing ITAK, and use of ITAK in therapies and in various assays, including assays to detect antagonists and agonists of ITAK are provided.
La présente invention concerne la kinase "ITAK" (IL-1/TNF-.alpha.-Activated Kinase) activée par l'interleukine-1 ou le facteur de nécrose tumorale .alpha., des acides nucléiques codant pour l'ITAK, des procédés de production de formes recombinantes de l'ITAK, des compositions pharmaceutiques contenant de l'ITAK, et l'utilisation de l'ITAK dans des thérapies et dans différents dosages, y compris des dosages visant à détecter des antagonistes et des agonistes de l'ITAL.
Anderson Dirk M.
Bird Timothy A.
Sims John E.
Virca G. Duke
Immunex Corporation
Smart & Biggar
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