C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/54 (2006.01)
Patent
CA 2533149
The present invention relates to new IL-11 muteins of which site I hydrophobocity has been increased. These muteins act as IL-11 agonist or hyperagonist, and are notably useful as anti-thrombocytopenia agents, and as agents improving the resistance of an organism to the deleterious in vivo effects induced by radiation or chemotherapy during the treatment of cancer or for the preparation of patient to transplantation.
La présente invention concerne de nouvelles mutéines IL-11 dont le caractère hydrophobe du site I a été augmenté. Ces mutéines agissent en tant qu'agonistes ou hyperagonistes de IL-11, et sont utiles notamment en tant qu'agents anti-thrombocytopénie, et en tant qu'agents pour améliorer la résistance d'un organisme aux effets délétères in vivo des rayonnements ou de la chimiothérapie au cours du traitement du cancer ou pour préparer un patient à une transplantation.
Content Jean
Grotzinger Joachim
Harmegnies Dimitri
Jacques Yannick
Paris Francois Emmanuel
Inserm (institut National de La Sante Et de La Recherche Medical
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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