A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/39 (2006.01) A61K 39/00 (2006.01) A61K 39/145 (2006.01)
Patent
CA 2322336
The present invention relates to a method of inducing a Th1-like response against a pathogen in a neonatal host, which comprises administering the neonatal host an effective amount of IL-12 and an antigen of the pathogen. Also encompassed by the present invention is a method of overcoming suppression of interferon-.gamma. (IFN-.gamma.) expression in a neonatal host due to exposure of the neonatal host to a pathogen or an antigen, which comprises administering to the neonatal host an effective amount of IL-12 and the antigen. The present invention also relates to a method of enhancing the cytokine expression against or in response to a pathogen in a neonatal host, which comprises administering to the neonatal host an effective amount of IL- 12 and an antigen of the pathogen.
L'invention porte sur un procédé d'induction d'une réponse du genre Th1 contre un agent pathogène dans un hôte néonatal consistant à administrer audit hôte une dose efficace d'IL-12, et un antigène de l'agent pathogène. L'invention porte également sur un procédé contrecarrant la suppression de l'expression de l'interféron-.gamma. (IFN-.gamma.) dans un hôte néonatal consistant à administrer audit hôte une dose efficace d'IL-12, et l'antigène. L'invention porte en outre sur un procédé renforçant l'expression de la cytokine contre ou en réponse à un agent pathogène dans un hôte néonatal, consistant à administrer audit hôte une dose efficace d'IL-12, et un antigène de l'agent pathogène.
Arulanandam Bernard P.
Metzger Dennis W.
Borden Ladner Gervais Llp
The Medical College Of Ohio
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