A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61P 11/00 (2006.01) A61P 37/08 (2006.01)
Patent
CA 2496948
The present invention relates to IL-13 vaccines and their use in the treatment of diseases that are treatable with neutralisation of IL-13, such as COPD, asthma and atopic disorders such as hayfever, contact allergies and atopic dermatitis. The vaccines of the present invention comprise an IL-13 immunogen and an adjuvant composition which is a combination of a saponin and a non- toxic derivative of LPS. The invention further relates to pharmaceutical compositions comprising such immunogens and their use in medicine and to methods for their production.
L'invention porte sur des vaccins IL-13 et sur leur utilisation dans le traitement de maladies pouvant être traitées par la neutralisation de IL-13, telles que les maladies obstructives respiratoires, l'asthme et les troubles atopiques tels que le rhume des foins, les allergies de contact et les dermatites atopiques. Les vaccins de l'invention contiennent un immunogène IL-13 et une composition d'adjuvant qui est une combinaison de saponine et d'un dérivé non toxique de LPS. Cette invention concerne aussi des compositions pharmaceutiques contenant ces immunogènes, et leur utilisation dans les médicaments, ainsi que leurs procédés de fabrication.
Ashman Claire
Ellis Jonathan Henry
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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