C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07K 14/54 (2006.01) C07K 14/715 (2006.01)
Patent
CA 2625694
The present invention relates to the stimulation of the IL-15Rbeta/gamma signalling pathway, to thereby induce and/or stimulate the activation and/or proliferation of IL-15Rbeta/gamma-positive cells, such as NK and/or T cells. Appropriate compounds include compounds comprising at least one IL- 15Rbeta/gamma binding entity, directly or indirectly linked by covalence to at least one polypeptide which contains the sushi domain of the extracellular region of an IL-15Ralpha.
L'invention se rapporte à la stimulation de la voie de signalisation de l'IL-15Rbêta/gamma, pour induire et/ou stimuler l'activation et/ou la prolifération de cellules positives à l'IL15Rbêta/gamma, telles que les cellules NK et/ou les lymphocytes T. Parmi les composés appropriés figurent les composants comportant au moins une entité de liaison à l'IL15Rbêta/gamma, qui est directement ou indirectement liée par covalence à au moins un polypeptide comprenant le domaine sushi de la région extracellulaire d'une IL-15Ralpha.
Jacques Yannick
Mortier Erwan
Plet Ariane
Quemener Agnes
Vusio Patricia
Institut National de La Sante Et de La Recherche Medicale (inser
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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