Il-16 antagonists

Details Il-16 antagonists Il-16 antagonists

C - Chemistry, Metallurgy

12

N

C12N 15/24 (2006.01) A61K 38/20 (2006.01) A61P 29/00 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2378778

The present invention has found that a series of peptides having sequences that substantially correspond to specific regions of the C-terminus of IL-16 can inhibit the activity of IL-16. The present invention has demonstrated that such IL-16-inhibiting peptides can be as short as 4 amino acid in length. Based on these discoveries, the present invention provides IL-16 antagonist peptides and the use thereof for the treatment of IL-16 mediated disorders such as certain inflammatory diseases.

La présente invention concerne une série de peptides possédant des séquences qui correspondent sensiblement aux régions spécifiques du C-terminal de l'interleukine-16, et qui peuvent inhiber l'activité de l'interleukine-16. Il a été démontré que les peptides pouvant inhiber l'activité de l'interleukine-16 peuvent être aussi courts en longueur que 4 acides aminés. La présente invention concerne donc des peptides antagonistes de l'interleukine-16 et leur utilisation dans le traitement des troubles associés à l'interleukine-16 comme certaines maladies inflammatoires.

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