C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/54 (2006.01) A61K 38/17 (2006.01) A61K 38/20 (2006.01) A61K 39/395 (2006.01) C07K 16/24 (2006.01) C12N 15/13 (2006.01) C12N 15/24 (2006.01) C12P 21/02 (2006.01) G01N 33/53 (2006.01) G01N 33/563 (2006.01)
Patent
CA 2530284
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin- 17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
La présente invention concerne une nouvelle cytokine humaine d'origine naturelle constituée d'un hétérodimère d'interleukine-17 et d'interleukine-17F, ci-après dénommé interleukine 17A/F (IL-17A/F). L'invention concerne également des vecteurs et des cellules hôtes contenant ces séquences d'acide nucléique; des molécules de polypeptides chimères contenant les polypeptides de l'invention fusionnés aux séquences de polypeptides hétérologues; des anticorps qui se lient spécifiquement aux polypeptides de l'invention; et des méthodes de production des polypeptides de l'invention. L'invention concerne en outre des méthodes de traitement de troubles cartilagineux dégénératifs et d'autres maladies inflammatoires.
Arnott David
Gurney Austin
Hass Philip
Lee James
Wu Yan
Genentech Inc.
Smart & Biggar
LandOfFree
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