A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/20 (2006.01) C07K 14/54 (2006.01) C07K 16/24 (2006.01)
Patent
CA 2666549
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17 A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
La présente invention concerne une nouvelle cytokine humaine naturelle constituée d'un hétérodimère d'interleukine 17 et d'interleukine 17F, connue sous le nombre d'interleukine 17A/F (IL-17 A/F). L'invention concerne également des vecteurs et des cellules hôtes comprenant ces séquences d'acides nucléiques, des molécules polypeptidiques chimériques comprenant les polypeptides de la présente invention fusionnés à des séquences de polypeptides hétérologues, des anticorps spécifiques se liant aux polypeptides de la présente invention, ainsi que des procédés de production des polypeptides de la présente invention. L'invention se rapporte en outre à des méthodes de traitement de troubles cartilagineux dégénératifs et d'autres maladies inflammatoires.
Arnott David P.
Balazs Mercedes
Ghilardi Nico
Gurney Austin L.
Hass Philip E.
Genentech Inc.
Smart & Biggar
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