Il-17c antagonists and methods of using the same

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/24 (2006.01) A61K 38/17 (2006.01) A61P 29/00 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2624763

The present invention relates IL-17RE antagonists, such as soluble receptors and anti-IL-17RE antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. IL-17RE is a receptor for IL-17C. The present invention includes soluble IL-17RE, anti- IL-17RE antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.

La présente invention concerne des antagonistes de IL-17RE, par exemple des récepteurs solubles et des anticorps anti-IL-17RE, qui peuvent être employés dans le blocage, l'inhibition, la réduction, l'antagonisme ou la neutralisation de l'activité de IL-17C. IL-17C est une cytokine impliquée dans des processus inflammatoires et des maladies humaines. IL-17RE est un récepteur de IL-17C. La présente invention inclut le IL-17RE soluble, des anticorps anti-IL-17RE et des partenaires de liaison, ainsi que des méthodes d'obtention d'un effet antagoniste vis-à-vis de IL-17C en employant de tels récepteurs solubles, de tels anticorps et de tels partenaires de liaison.

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