C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/24 (2006.01) A61K 38/17 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 5/16 (2006.01) C12N 15/12 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2666842
The present invention relates IL-17RE antagonists, such as soluble receptors and anti-IL-17RE antibodies, which are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. IL-17RE is a receptor for IL-17C. The present invention includes soluble IL-17RE, soluable fusion peptide comprising one or more IL-17RE domains anti-IL-17RE antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.
La présente invention concerne des antagonistes de l'IL-17RE, tels que des récepteurs solubles et des anticorps anti-IL-17RE, qui se révèlent utiles pour bloquer, inhiber, réduire, produire des effets antagonistes ou neutraliser l'activité de l'IL-17C. L'IL-17C est une cytokine qui est impliquée dans des processus inflammatoires et des maladies humaines. L'IL-17RE est un récepteur de l'IL-17C. La présente invention concerne un IL-17RE soluble, un peptide de fusion soluble contenant un ou plusieurs anticorps anti-IL-17RE et partenaires de liaison des domaines de l'IL-17RE, ainsi que des procédés permettant de produire un effet antagoniste sur l'IL-17C au moyen de tels récepteurs solubles, anticorps et partenaires de liaison.
Appleby Mark W.
Birks Carl W.
Gao Zeren
Kuestner Rolf E.
Lewis Kenneth B.
Osler Hoskin & Harcourt Llp
Zymogenetics Inc.
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