Il-17ra-il-17rb antagonists and uses thereof

Details Il-17ra-il-17rb antagonists and uses thereof Il-17ra-il-17rb antagonists and uses thereof

A - Human Necessities

61

K

A61K 39/395 (2006.01) C07K 14/715 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2715503

The present invention relates to Interleukin-17 ligand and receptor family members and the discovery that IL-17 receptor A and IL-17 receptor C form a heteromeric receptor complex that is biologically active. Antagonists of the IL-17RA- IL-17RB heteromeric receptor complex are disclosed, as well as various methods of use.

La présente invention concerne des ligands dinterleukine-17 et des membres de la famille des récepteurs de linterleukine-17, et la découverte que le récepteur A de lIL-17 et le récepteur C de lIL-17 forment un complexe réceptoriel hétérodimère biologiquement actif. Des antagonistes du complexe réceptoriel hétérodimère IL-17RA-IL-17RB sont décrits, ainsi que divers procédés pour les utiliser.

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