Il-23p40 specific immunoglobulin derived proteins,...

Details Il-23p40 specific immunoglobulin derived proteins,... Il-23p40 specific immunoglobulin derived proteins,...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 49/00 (2006.01) C07K 16/24 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2525184

Novel anti-IL-23p40 specific human Ig derived proteins, including, without limitation, antibodies, fusion proteins, and mimetibodies, isolated nucleic acids that encode the anti-IL-23p40 Ig derived proteins, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, are useful for therapeutic compositions, methods and devices. Preferably, the anti- IL-23p40 specific human Ig derived proteins do not bind the p40 subunit of IL- 12 and, thus, do not neutralize IL-12-related activity.

L'invention a trait à de nouvelles protéines dérivées de Ig humaines spécifiques anti-IL-23p40, lesquelles comprennent, sans limitation, des anticorps, des protéines hybrides et des corps mimétiques, ainsi qu'à des acides nucléiques isolés qui codent lesdites protéines dérivées de Ig anti-IL-23p40, à des vecteurs, à des cellules hôtes, à des animaux ou des plantes transgéniques, et à des procédés de production et d'utilisation de ceux-ci, lesquels sont utiles pour des compositions, des méthodes et des dispositifs thérapeutiques. De préférence, les protéines dérivées de Ig humaines spécifiques anti-IL-23p40 ne se lient pas à la sous-unité p40 de IL-12 et, ainsi, ne neutralisent pas l'activité associée à IL-12.

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