Il-28 polypeptides and polynucleotids

Details Il-28 polypeptides and polynucleotids Il-28 polypeptides and polynucleotids

C - Chemistry, Metallurgy

12

N

C12N 15/19 (2006.01) C12N 5/078 (2010.01) A61K 38/19 (2006.01) A61K 38/21 (2006.01) C07K 14/52 (2006.01) C07K 14/54 (2006.01) C07K 14/555 (2006.01) C07K 14/56 (2006.01) C07K 16/24 (2006.01) C12N 15/21 (2006.01)

Patent

CA 2441958

The present invention relates to polynucleotide and polypeptide molecules for zcyto20, zcyto21, zcyto22, zcyto24 and zcyto25 proteins which are most closely related to interferon-.alpha. at the amino acid sequence level. The receptor for this protein family is a class II cytokine receptor. The present invention includes methods of reducing viral infections and increasing monocyte counts. The present invention also includes antibodies to the zcyto20 polypeptides, adn methods of producing the polynucleotides and polypeptides.

L'invention concerne des molécules de polynucléotides et de polypeptides pour les protéines zcyto20, zcyto21, zcyto22, zcyto24 et zcyto25, lesquelles sont plus étroitement liées à l'interféron-.alpha. au niveau de la séquence d'acides aminés. Le récepteur pour cette famille protéique est un récepteur de cytokine de classe II. La présente invention concerne des méthodes permettant de réduire des infections virales et d'augmenter la quantité de monocytes. Cette invention concerne également des anticorps dirigés contre les polypeptides zcyto20, et des procédés permettant d'élaborer les polynucléotides et les polypeptides.

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