Il-31 monoclonal antibodies and methods of use

Details Il-31 monoclonal antibodies and methods of use Il-31 monoclonal antibodies and methods of use

C - Chemistry, Metallurgy

07

K

C07K 16/24 (2006.01) A61P 17/00 (2006.01) A61P 17/04 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2607588

The present invention relates to methods of treating pruritic diseases, including but not limited to Contact dermatitis, Atopic Dermatitis, Drug induced delayed type cutaneous allergic reactions, Toxic epidermal necrolysis, Cutaneous T cell Lymphoma, Bullous pemphigoid, Alopecia wereata, Vitiligo, Acne Rosacea, Prurigo nodularis, Scleroderma, Herpes simplex virus, or combination thereof by administering IL-31 monoclonal antibodies. The invention further provides the hybridomas that generate the monoclonal antibodies.

L'invention porte sur des procédés de traitement de maladies pruritiques, y compris, entre autres, la dermite de contact, la dermite atopique, des réactions allergiques cutanées de type différé à induction médicamenteuse, la nécrolyse épidermique toxique, le lymphome T cutané, la pemphigoïde bulleuse, l'alopécie wereata, le vitiligo, la rosacée, le prurigo nodularis, sclérodermie, le virus de l'herpès simplex, ou une combinaison de ceux-ci par administration des anticorps monoclonaux IL-31. Cette invention se rapporte aussi à des hybridome qui génèrent les anticorps monoclonaux.

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