Il-32 modulators

Details Il-32 modulators Il-32 modulators

G - Physics

01

N

G01N 33/68 (2006.01) A61K 31/00 (2006.01) A61K 38/00 (2006.01) C07K 14/00 (2006.01)

Patent

CA 2614680

The present invention relates to methods of screening for modulators of interleukin 32 (IL-32), to modulators of IL-32 and to their use. Proteinase 3 has been identified as an IL-32 binding protein capable of deavege thereof. Inhibition of PR 3 activity to process IL-32 or neutralization of IL-32 by- inactive PR3 or its fragments may reduce the consequences of IL-32 in immune regulated diseases (e.g. inflammatory diseases).

L'invention concerne des procédés de criblage de modulateurs de l'interleukine 32 (IL-32), des modulateurs de l'IL-32 et l'utilisation de ceux-ci.

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