Il-5 inhibiting 6-azauracil derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 253/075 (2006.01) A61K 31/53 (2006.01) A61P 11/06 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01)

Patent

CA 2352275

The present invention is concerned with the compounds of formula (I), the N- oxides, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein p is 0 to 3; q is 0 to 5; -A-B- is -(CH2)r-, -(CH2)t-O-, -(CH2)t-S(-O)u- or -(CH2)t-NR3-; to processes for their preparation and compositions comprising them. It further relates to their use as a medicine.

Cette invention se rapporte aux composés représentés par la formule (I), aux N-oxydes, aux sels d'addition pharmaceutiquement acceptables et aux formes stéréochimiquement isomères de ces composés, formule dans laquelle p est compris entre 0 et 3, q est compris entre 0 et 5, A-B- représente (CH2)r-, (CH)t-O-, (CH2)t-S(=O)u- ou (CH2)t-NR<3>-; à des procédés de préparation de ces composés et à des compositions comprenant ces composés. Cette invention se rapporte en outre à l'utilisation de ces composés comme médicament.

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