Il-6 antagonist peptides

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/715 (2006.01) A61K 38/04 (2006.01) A61K 38/16 (2006.01) A61P 37/02 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/54 (2006.01)

Patent

CA 2332817

The present invention relates to IL-6 antagonist peptides, isolatable from a peptide library through the two-hybrids system by their ability to bind to the intracellular domain of gp130 and containing at least 5 amino acids. In particular, such peptides comprise an amino acid sequence, which is selected from the group consisting of: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, as well as salts, functional derivatives, precursors and analogs thereof. Another object of the present invention is to provide the peptide in substantially purified form, in order to be suitable for use in pharmaceutical compositions as active ingredient in pathologies that require IL-6 activity inhibition.

Dans la présente invention, on divulgue des peptides antagonistes de l'IL-6, qu'on peut isoler d'une bibliothèque peptides au moyen d'un système à deux hybrides grâce à leur capacité à se lier au domaine intracellulaire de gp 130, et qui contiennent au moins 5 acides aminés. De tels peptides comprennent notamment une séquence d'acides aminés, choisie dans le groupe constitué par les séquences suivantes: SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8. Dans la présente invention, on divulgue également des sels, des dérivés fonctionnels, des précurseurs et des analogues de ces peptides. Par ailleurs, un autre objectif de la présente invention est d'obtenir ce peptide sous forme sensiblement purifiée, de manière à pouvoir l'utiliser adéquatement dans des compositions pharmaceutiques en tant que principe actif pour des pathologies nécessitant l'inhibition de l'activité de l'IL-6.

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