Il-7 fusion proteins

Details Il-7 fusion proteins Il-7 fusion proteins

C - Chemistry, Metallurgy

07

K

C07K 14/54 (2006.01) A61K 38/04 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2551915

The invention relates to interleukin-7 (IL-7) fusion proteins, methods of their production and uses thereof. The fusion proteins comprise an immunoglobulin portion fused directly or indirectly to IL-7, which was modified at specific positions as compared to the wild~type IL-7 in order to improve biological and pharmaceutical properties. The proteins of the invention are particularly useful in treating disorders accompanied by immune deficiencies and particularly diseases which involve T-cell deficiencies.

L'invention concerne des protéines de fusion d'interleukine-7 (IL-7, des méthodes servant à les préparer et leurs utilisations. Ces protéines de fusion comprennent une partie d'immunoglobuline fusionnée directement ou indirectement à IL-7, qui a été modifiée au niveau de positions spécifiques par rapport au type sauvage d'IL-7 de façon à en améliorer les propriétés biologiques et pharmaceutiques. Ces protéines sont particulièrement utiles pour traiter des troubles associés à des déficiences immunes et, en particulier, des maladies impliquant des déficiences des lymphocytes T.

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