Il13 mutants

Details Il13 mutants Il13 mutants

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/20 (2006.01) C07K 14/54 (2006.01) C12N 15/24 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2386248

This invention provides mutant human interleukin 13 molecules showing varying specificity for the restricted (IL4 independent) IL13 receptor. The mutant hIL13 molecules include those made by substituting the amino acid residues that occur in the alpha-helix regions of native hIL13 with various other amino acid residues. Some of the mutants retain the ability to bind and cause signaling through IL13 receptors, while other mutants do not.

L'invention concerne des molécules d'interleukine 13 humaine mutantes faisant preuve d'une spécificité différente pour le récepteur limité de l'IL13 (indépendant de l'IL14). Les molécules de l'hIL13 mutantes sont constituées de celles formées par substitution des restes d'acides aminés présents dans les zones sous forme d'alpha hélice d'hIL13 native avec d'autres restes d'acides aminés. Certains mutants conservent la capacité de se lier et d'assurer la signalisation à travers les récepteurs d'IL13 au détriment d'autres mutants.

Affiliated with

Also associated with

Rating

Il13 mutants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Il13 mutants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Il13 mutants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1819611