A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/20 (2006.01) A61P 31/12 (2006.01)
Patent
CA 2616122
IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
L'invention concerne IL-28A, IL-28B, IL-29 et certains mutants de ceux-ci possédant une activité antivirale sur un spectre d'espèces virales. L'invention concerne spécialement l'activité antivirale démontrée sur des virus attaquant le foie, tels que les virus de l'hépatite B et de l'hépatite C. de plus, IL-28A, IL-28B, IL-29 et les mutants de ceux-ci ne possèdent pas une partie de l'activité anti-proliférative sur des cellules hématopoïétiques observée avec un traitement par interférons. Sans les effets immunosuppresseurs accompagnant le traitement par interférons, IL-28A, IL-28B et IL-29 seront utiles dans le traitement de patients immunodéprimés souffrant d'infections virales.
Bristol-Myers Squibb Company
Smart & Biggar
Zymogenetics Inc.
Zymogenetics Llc
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