Il8 inhibitors

Details Il8 inhibitors Il8 inhibitors

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2171289

Inhibitors, including antibodies, of IL8 binding to its receptors, that interact with the amino-terminal extracellular domain of the IL8 receptor and which compete with IL8 for receptor-binding, are disclosed. The inhibitors are useful modulators of IL8 receptor-mediated biological activity.

Inhibiteurs, y compris anticorps, de la liaison de l'IL8 à ses récepteurs, qui interagissent avec le domaine extracellulaire amino-terminal du récepteur de l'IL8 et qui sont en concurrence avec l'IL8 pour la liaison auxdits récepteurs. Lesdits inhibiteurs sont des modulateurs utiles de l'activité biologique induite par le récepteur de l'IL8.

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