Illudin analogs as anti-tumor agents

Details Illudin analogs as anti-tumor agents Illudin analogs as anti-tumor agents

C - Chemistry, Metallurgy

07

C

C07C 49/587 (2006.01) A61K 31/12 (2006.01) A61K 31/215 (2006.01) A61K 31/22 (2006.01) A61K 31/27 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07C 45/45 (2006.01) C07C 45/46 (2006.01) C07C 45/65 (2006.01) C07C 45/67 (2006.01) C07C 49/67 (2006.01) C07C 49/683 (2006.01) C07C 49/737 (2006.01) C07C 49/747 (2006.01) C07C 49/753 (2006.01) C07C 49/755 (2006.01) C07C 69/007 (2006.01) C07C 271/12 (2006.01)

Patent

CA 2067365

A method of inhibiting tumor cell growth in a subject is provided comprising contacting the tumor with a therapeutic amount of an illudin S or illudin M analog having structure (I) or (II), wherein the analog is capable of inhibiting tumor cell growth without excessive toxicity to the subject and wherein R1 is an alkyl or hydrogen; R2 is an alkyl; and R3 is an alcohol or ester.

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