Ilt-2 (liri) variants with increased affinity for mhc class...

Details Ilt-2 (liri) variants with increased affinity for mhc class... Ilt-2 (liri) variants with increased affinity for mhc class...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/00 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2670446

The present invention provides ILT-2 variants having the property of binding to a given Class IpMHC with a KD of less than or equal to lµM and/or an off-rate (Koff) of 2 S-1 or slower AND said polypeptide has at least a 45% identity and/or 55% similarity to SEQ ID NO: 19 AND said polypeptide inhibits CD8 binding to the given pMHC to a greater extent than the polypeptide SEQ ID NO: 3, CHARACTERISED IN THAT said polypeptide comprises an amino acid sequence selected from one of SEQ ID NOs 6 to 69. Such polypeptides are useful, either alone or associated with a therapeutic agent, for the inhibition of cyto-toxic T cell (CTL) responses.

La présente invention concerne des variantes du transcrit ILT-2 ayant la propriété de se lier à un PMHC de classe I donné avec une constante KD inférieure ou égale à 1 µM et/ou une vitesse de dissociation (Coff) inférieure ou égale à 2 s-1, ledit polypeptide ayant une identité d'au moins 45 % et/ou une similitude d'au moins 55 % par rapport à la SEQ ID n° : 19 et ledit polypeptide inhibant mieux la liaison du CD8 au pMHC donné que le polypeptide de la SEQ ID n° : 3, caractérisées en ce que ledit polypeptide comprend une séquence d'acides aminés sélectionnée parmi l'une des SEQ ID nos 6 à 69. De tels polypeptides sont utiles, soit seuls soit en association avec un agent thérapeutique, pour l'inhibition de réponses des lymphocytes T cytotoxiques (CTL).

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