Image-guided therapy of myocardial disease: composition,...

A - Human Necessities – 61 – K

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A61K 49/10 (2006.01) A61K 31/165 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2719623

Compositions and methods for imaging and for chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns agents comprising a targeting moiety comprising a beta- adrenergic receptor targeting compound conjugat-ed or embedded with ethylenediamine. The present invention also concerns methods of application of such agents for imaging and treatment of cardiovascular diseases, and kits for preparing a radiolabeled therapeutic or diagnostic agent.

La présente invention concerne des compositions et des procédés pour limagerie et pour la chimiothérapie et la radiothérapie. Plus particulièrement, linvention concerne des agents comportant un fragment de ciblage comportant un composé de ciblage du récepteur bêta-adrénergique conjugué ou incorporé avec de léthylène-diamine. La présente invention concerne également des procédés dapplication de tels agents pour limagerie et le traitement de maladies cardiovasculaires, et des trousses pour la préparation dun agent thérapeutique ou diagnostique identifié à laide dun marqueur radioactif.

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