Imageable rodent model of asthma

C - Chemistry – Metallurgy – 12 – Q

Patent

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C12Q 1/00 (2006.01) C12Q 1/06 (2006.01)

Patent

CA 2700543

An imageable rodent model for asthma is described. The invention provides a rodent model for asthma wherein a rodent is provided with fluorescently labeled lymphocytes sensitized to an allergen which can be monitored after inducing an asthmatic response by the allergen. Methods to monitor trafficking of the fluorescently labeled cells in the rodent model for asthma are provided. Methods to determine the effectiveness of candidate drugs that regulate asthmatic responses using the rodent asthma model are also provided.

L'invention concerne un modèle d'asthme de rongeur imageable. L'invention propose un modèle d'asthme de rongeur. Selon l'invention, un rongeur reçoit des lymphocytes marqués par fluorescence sensibilisés à un allergène qui peuvent être surveillés après l'induction d'une réponse asthmatique par l'allergène. Des procédés de surveillance du trafic des cellules marquées par fluorescence dans le modèle d'asthme de rongeur sont proposés. Des procédés de détermination de l'efficacité de médicaments candidats qui régulent les réponses asthmatiques à l'aide du modèle d'asthme de rongeur sont également proposés.

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