C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 211/26 (2006.01) A61K 51/04 (2006.01) C07D 211/60 (2006.01) C07D 401/12 (2006.01) C07F 13/00 (2006.01)
Patent
CA 2400856
Generally, the present invention is directed to central nervous system dopamine transporter-imaging agents and methods of use thereof. In certain embodiments, the present invention relates to radiolabeled piperidine derivatives for use as imaging agents in the diagnosis of Parkinson's disease. Another aspect of the present invention relates to piperidine monoamine transporter ligands, comprising a functional group capable of chelating a radionuclide, e.g., technetium, and methods of use thereof.
L'invention concerne des agents d'imagerie de transporteurs de dopamine du système nerveux central et des procédés d'utilisation de ceux-ci. Dans certains modes de réalisation, la présente invention concerne des dérivés de pipéridine radiomarqués servant d'agents d'imagerie dans le diagnostic de la maladie de Parkinson. Dans un autre mode de réalisation, la présente invention concerne des ligands de transporteurs de monoamine de pipéridine, comportant un groupe fonctionnel pouvant chélater un radionucléide, par ex. le technétium, ainsi que des procédés d'utilisation de ces ligands.
Babich John W.
Smith Miles P.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Biostream Therapeutics Inc.
Molecular Insight Pharmaceuticals Inc.
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