Imaging cardiac infarcts with radioactive metals complexed...

C - Chemistry – Metallurgy – 07 – F

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C07F 9/38 (2006.01) A61K 51/04 (2006.01)

Patent

CA 1254508

ABSTRACT OF THE DISCLOSURE The imaging of cardiac infarcts with complexed radioactive metals is improved by employing as the complexing agent a compound of the formula Image wherein substituents A, B, X, and Y are each independently selected from radicals including hydrogen; hydroxyalkyl (wherein the alkyl group contains 2-6 carbon atoms); phosphonic; sulfonic; methylenephosphonic; methylene-, ethylene-, and propylenesulfonic; carboxylic acid radicals (having 2-4 carbon atoms); and the alkali metal, alkaline earth metal, ammonia, and amine salts thereof; and wherein at least one of A, B, X, or Y is methylenephosphonic acid or a salt thereof. In particular Tc-99m complexes have been found useful for imaging damaged cardiac tissue.

463084

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