Imaging contrast agents using nanoparticles

A - Human Necessities – 61 – K

Patent

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A61K 9/14 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2663770

The present invention relates to a nanoparticle comprising self- assembled crosslinked, amphiphilic block copolymers and at least one immobilized dye, wherein the sell-assembled, crosslinked, amphiphilic block copolymers comprise a hydrophilic block and a hydrophobic block, wherein the self-assembled, crosslinked, amphiphilic block copolymers are self-assembled to form a core of the nanoparticle comprising a hydrophobic block, wherein the hydrophobic block is derived from at least one pendant multifunctional crosslinked alkoxy silane or amino silane moiety, and an exterior of the nanoparticle comprising a hydrophilic block, and wherein the immobilized dye is immobilized in the core

L'invention concerne une nanoparticule comprenant des copolymères séquencés amphiphiles réticulés auto-assemblés et au moins un colorant immobilisé, lesdits copolymères séquencés comprenant un bloc hydrophile et un bloc hydrophobe. Ces copolymères sont auto-assemblés de sorte que le cAEur de la nanoparticule comprend un bloc hydrophobe, ce bloc hydrophobe étant obtenu à partir d'au moins une fraction alcoxy silane ou amino silane réticulée multifonctionnelle latérale, et l'extérieur de la nanoparticule comprenant un bloc hydrophile, le colorant immobilisé étant immobilisé dans le cAEur.

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