Imaging systems featuring waveguiding compensation

A - Human Necessities – 61 – B

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A61B 5/00 (2006.01)

Patent

CA 2740602

There are systems and methods for altering an image to compensate for variation in one or more physical and/or supervenient properties (e.g., optical absorption and/or scattering) in heterogeneous, diffuse tissue, thereby attenuating the effects of tissue waveguiding. The methods enable the proper identification of emission image regions that evidence waveguiding of electromagnetic radiation, and enables compensation of emission images for such waveguiding. The methods preserve the depth localization accuracy of the FMT approach and improve optical reconstruction in the targeted areas while eliminating spurious components of fluorescence from the acquired data set. Calibration methods for probe concentration mapping are also presented.

Dans certains modes de réalisation, la présente invention concerne des systèmes et des procédés permettant de modifier une image pour compenser les modifications d'une ou plusieurs propriétés physiques et/ou qui apparaissent (par exemple, l'absorption et/ou la diffusion optique) dans un tissu diffus hétérogène, atténuant de cette façon les effets du guidage d'ondes dans les tissus. Les procédés permettent l'identification correcte des régions d'images d'émission qui témoignent du guidage d'ondes des radiations électromagnétiques, et permettent la compensation des images d'émission pour ce guidage d'ondes. Les procédés préservent la précision de la localisation de profondeur de l'approche FMT et améliorent la reconstruction optique dans les zones ciblées tout en éliminant les composants de fluorescence parasites du jeu de données acquis. L'invention présente également des procédés d'étalonnage pour la cartographie des concentrations de la sonde.

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